Hecatomb is a pipeline for accurately classifying viral sequences in metagenome samples.

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The pipeline is the brainchild of Scott Handley and his group at Washington University in St. Louis:

“A hecatomb is a great sacrifice; a great number of people, animals or things, especially as sacrificed or destroyed. In this case we provide a hecatomb of false-positive viral sequences.”

Rob and I have been working with Scott to help finish development of the pipeline and it has recently seen a number of quality of life improvements. The pipeline runs via Snakemake and Snaketool, utilising Conda/Mamba for ease of installation and use, as well as improved scalability and robustness. The pipeline now has scripts for downloading and installing the databases and adding new host genomes. A convenience launcher has also been included to make running these jobs super simple.

For more information please don’t hesitate to email me.

Poster for ASM 2021